I have a Trigger setup to take tickets where a specific Macro was used and set a Due Date field to a number of days later. We have tickets toggle back to open when the Due Date is Today's Date.
Our customers are all businesses though, is there a way to set it to a number of Business Days from now?
Basically the same option as below but "Set to a number of Business Days days from now" instead.
If not the only thing I can think to do is make our automation that opens the ticket to only set them to Open on a business day.

What you’re looking for—setting a Due Date based on a number of business days rather than calendar days—is a common request. Unfortunately, Zendesk triggers currently only support setting the Due Date as a specific date or a number of calendar days from now, not business days.
As you mentioned, one workaround is to use automations to reopen or adjust tickets only on business days or create custom business hour logic through business rules combined with scheduling. Another potential option is exploring Zendesk Apps or integrations that add this functionality, or leveraging Zendesk’s APIs to calculate and set Due Dates based on business days programmatically.
For more details on trigger conditions and actions, check the Ticket trigger conditions and actions reference.
Hopefully, Zendesk will add native business day calculations in the future, but until then, a mix of automations, scheduling, or custom development is the way to go.
Good luck!